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NASDAQ · PHARMACEUTICAL PREPARATIONS · LARGE CAP

Alnylam Pharmaceuticals, Inc. ALNY

18 fiscal years on record · USD · FY2025 reported · SEC filings only
$3.7B
▲ 65.2% YoY
$313.7M
$465.4M

Slide the table for earlier years · "·" marks a figure not available in our data for that year.

In brief

What this company does

Alnylam Pharmaceuticals, Inc. is a global commercial-stage biopharmaceutical company that develops therapeutics based on ribonucleic acid interference, or RNAi. It currently has six marketed products, including two commercialized by collaborators, and more than 20 clinical programs, including several in late-stage development. As of December 31, 2025, it employed approximately 2,500 full-time employees, of whom approximately 1,945 were employed in the U.S. and approximately 555 were employed outside of the U.S. AMVUTTRA is approved for the treatment of hereditary transthyretin-mediated amyloidosis with polyneuropathy in the United States, for hATTR amyloidosis with stage 1 or stage 2 polyneuropathy in the European Union and the United Kingdom, for transthyretin-type familial amyloidosis with polyneuropathy in Japan, and in multiple additional countries. Alnylam Pharmaceuticals, Inc. is a Delaware corporation that was formed in May 2003.

Written from the business description in ALNYLAM PHARMACEUTICALS, INC.'s annual report to the U.S. Securities and Exchange Commission, filed 12 February 2026. Every sentence was checked against that document before publication.

Growth

USD 3.7B
Revenue, FY2025 · full 18-year series below
Revenue $B Net income $B
FY2025 · Revenue 3.7 · Net income 0.3
1.5B3.0B-0.5B-1.0B
2008201120142017202020232025
Compound annual growth
+53.0%
+49.8%
3 yrs
5 yrs
10 yrs
15 yrs

Revenue compounded at +49.8% a year over the five years to FY2025.

Compound annual rates per period — left blank where that exact year isn't on file, the series crosses a loss, or (per-share rows) a split falls inside the window.

Profitability

8 cents
of every revenue dollar became profit
Operating margin Net margin
FY2025 · Operating 13.5% · Net 8.4%
-500%-1000%
200820162025
ROE
FY2025 · ROE 73.3%
20%40%60%-50%-100%
200820162025
Three returns, three denominators.

Each USD of equity produced 73 cents of profit this year.

Cash & shareholders

·
returned in FY2025 · dividends + net buybacks
Free cash flow $M
FY2025 · FCF 465.4
200M400M-300M-600M
200820162025

Total assetsUSD 5.0B
EquityUSD 789.2M
CashUSD 1.7B
Current ratio2.76×

Equity funds 16% of total assets.

The 18-year record

18 fiscal years
Every figure from documents filed with the SEC · USD
row low → row highnegative—not applicable◌not available in our data
ALNY, 18-year financial record
Metric 202520242023202220212020201920182017201620152014201320122011201020092008
Revenue $B3.72.21.81.00.80.50.20.10.10.0◌◌◌◌◌0.10.10.1
Operating income $B0.5−0.2−0.3−0.8−0.7−0.8−0.9−0.8−0.5−0.4−0.3−0.4−0.1−0.1−0.1−0.0−0.0−0.0
EBITDA $B0.6−0.1−0.2−0.7−0.7−0.8−0.9−0.8−0.5−0.4−0.3−0.4−0.1−0.1−0.0−0.0−0.0−0.0
Income tax $B0.0−0.10.00.00.00.00.00.00.00.00.0−0.0−0.0−0.00.00.00.00.0
Net income $B0.3−0.3−0.4−1.1−0.9−0.9−0.9−0.8−0.5−0.4−0.3−0.4−0.1−0.1−0.1−0.0−0.0−0.0
Free cash flow $B0.5−0.00.0−0.6−0.7−0.7−0.4−0.7−0.5−0.4−0.2−0.2−0.1−0.1−0.1−0.1−0.10.1
EPS, diluted $2.33−2.18−3.52−9.30−7.20−7.46−8.11−7.57−5.42−4.79−3.45−4.85−1.45−2.11−1.36−1.04−1.14◌
Dividend / sh $◌◌◌◌◌◌◌◌◌◌◌◌◌◌◌◌◌◌
Payout % — not applicable: no dividend——————————————————
ROE %73.3———−106.3−69.9−64.7−49.6−36.5−37.5−26.4−59.7−44.1−84.1−41.7−25.9−25.0−13.0
Shares out B0.130.130.130.120.120.120.110.100.100.090.090.080.060.050.040.040.04◌

Slide the table for earlier years. "—" not applicable · "◌" not available in our data.

More in this sector

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Provenance

Company facts, as filed

How we verify · 0 failures in 68 reconciliationsAUDITED

Reconciled in 18 of the 18 fiscal years we could check. 10 checks were skipped: cost of revenue is not tagged before 2017. Four checks were skipped: the balance sheet is not tagged before 2009. Three checks were skipped: the share count is not tagged before 2010.

EPS recomputationBalance-sheet identityGross profitBalance-sheet liquidityCurrency consistency0 failures
ActivityPharmaceutical Preparations
Listed onNASDAQ
Incorporated innot stated in the filings
Fiscal year endsDecember 31
Data on record since2008

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