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MARKETS / NASDAQ / RARE
NASDAQ · PHARMACEUTICAL PREPARATIONS · LARGE CAP

Ultragenyx Pharmaceutical Inc. RARE

14 fiscal years on record · USD · FY2025 reported · SEC filings only
$673.0M
▲ 20.2% YoY
$-575.0M
$-472.0M
In brief

What this company does

For the year ended December 31, 2025, 45% of its total revenues were generated by its collaboration partner KKC. Its current approved therapies and clinical-stage pipeline consist of four product categories: biologics, small molecules, AAV gene therapy, and nucleic acid product candidates. Crysvita is approved in the U.S., the EU and certain other regions for the treatment of XLH in adult and pediatric patients one year of age and older. Evkeeza is approved in the U.S., where it is marketed by the company's partner Regeneron Pharmaceuticals, and is also approved in the European Economic Area, Brazil, Mexico, and Japan as a first-in-class therapy for use together with diet and other LDL-C lowering therapies. It was founded in April 2010 by its President and Chief Executive Officer, Emil Kakkis, M.D., Ph.D.

Written from the business description in Ultragenyx Pharmaceutical Inc.'s annual report to the U.S. Securities and Exchange Commission, filed 18 February 2026. Every sentence was checked against that document before publication.

Growth
USD 673.0M
Revenue, FY2025 · full 14-year series below
Revenue $M Net income $M
FY2025 · Revenue 673.0 · Net income -575.0
250.0M500.0M-250.0M-500.0M20122014201620182020202220242025
Compound annual growth
+22.8%
+19.9%
3 yrs
5 yrs
10 yrs
15 yrs

Revenue compounded at +19.9% a year over five years.

Compound annual rates per period — left blank where that exact year isn't on file, the series crosses a loss, or (per-share rows) a split falls inside the window.

Profitability
−85 cents
lost on every revenue dollar
Operating margin Net margin
FY2025 · Operating -79.5% · Net -85.4%
-50000%-100000%-150000%20122014201620182020202220242025
ROE
FY2025 · ROE -657.1%
-200%-400%-600%20122014201620182020202220242025

Each USD of equity lost 657 cents this year.

Cash & shareholders
returned in FY2025 · dividends + net buybacks
Free cash flow $M
FY2025 · FCF -472.0
-200M-400M20122014201620182020202220242025

Total assetsUSD 1.5B
EquityUSD -80.0M
CashUSD 421.0M
Current ratio2.48×

Equity funds -5% of total assets.

The 14-year record
14 fiscal years
Every figure from documents filed with the SEC · USD

EPS, diluted, dividend per share and shares outstanding are shown without shading, and a vertical line marks the year the share count changed — the series crosses a large, unexplained change in share count, so the years on either side are not on a comparable scale.

row low → row highnegative
Metric 20252024202320222021202020192018201720162015201420132012
Revenue $B0.70.60.40.40.40.30.10.10.00.0····
Operating income $B−0.5−0.5−0.6−0.6−0.4−0.3−0.4−0.4−0.3−0.2−0.1−0.1−0.0−0.0
EBITDA $B−0.5−0.5−0.5−0.6−0.4−0.3−0.4−0.4−0.3−0.2−0.1−0.1−0.0−0.0
Income tax $B0.00.0−0.00.00.00.00.00.0−0.00.00.00.00.0·
Net income $B−0.6−0.6−0.6−0.7−0.5−0.2−0.4−0.2−0.3−0.2−0.1−0.1−0.0−0.0
Free cash flow $B−0.5−0.4−0.5−0.5−0.4−0.2−0.4−0.3−0.3−0.2−0.1−0.0−0.0−0.0
EPS, diluted $−5.83−6.29−8.25−10.12−6.70−3.07−7.12−3.97−7.12−6.21−3.96−2.25−14.87−14.20
Dividend / sh $··········0.000.00··
Payout %··············
ROE %−657.1−214.7−193.6−111.0−43.7−20.6−63.8−39.8−70.5−48.9−40.7−108.6··
Shares out B0.100.090.080.070.070.070.060.050.040.040.040.030.00·

Slide the table for earlier years · "·" marks a figure not available in our data for that year.

Provenance
Company facts, as filed
How we verify · 1 failures · 1 divergences in 54 reconciliationsAUDITED

Reconciled in 12 of 19 fiscal years. 1 of those reconciliations are divergences — the figures exist but don't fit the formula this check expects; that isn't the same as an error. 39 checks could not be computed.

EPS recomputationBalance-sheet identityGross profitBalance-sheet liquiditymoeda_consistente1 failures1 divergent
ActivityPharmaceutical Preparations
Listed onNASDAQ
Incorporated inDelaware
Fiscal year endsDecember 31
Data on record since2012

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