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MARKETS / NASDAQ / SPRO
NASDAQ · PHARMACEUTICAL PREPARATIONS · SMALL CAP

Spero Therapeutics, Inc. SPRO

11 fiscal years on record · USD · FY2025 reported · SEC filings only
$12.6M
▲ 3292.5% YoY
$8.6M
In brief

What this company does

Since our inception in 2013, we have focused our efforts and financial resources on acquiring and developing product and technology rights, building our intellectual property portfolio and conducting research and development activities for our product candidates. We were formed as Spero Therapeutics, LLC in December 2013 under the laws of the State of Delaware. Our principal executive offices are located at 675 Massachusetts Avenue, 14th Floor, Cambridge, Massachusetts 02139, and our telephone number is (857) 242-1600. As of December 31, 2025, we had 25 employees, including a total of 6 employees with M.D. or Ph.D. degrees.

Written from the business description in Spero Therapeutics, Inc.'s annual report to the U.S. Securities and Exchange Commission, filed 26 March 2026. Every sentence was checked against that document before publication.

Growth
USD 12.6M
Revenue, FY2025 · full 11-year series below
Revenue $M Net income $M
FY2025 · Revenue 12.6 · Net income 8.6
8M16M-40M-80M201520172019202120232025
Compound annual growth
+71.3%
+117.6%
3 yrs
5 yrs
10 yrs
15 yrs

Revenue compounded at +117.6% a year over five years.

Compound annual rates per period — left blank where that exact year isn't on file, the series crosses a loss, or (per-share rows) a split falls inside the window.

Profitability
68 cents
of every revenue dollar became profit
Operating margin Net margin
FY2025 · Operating 50.2% · Net 68.1%
-10000%-20000%-30000%201520172019202120232025
ROE
FY2025 · ROE 16.3%
10%20%-50%-100%-150%201520172019202120232025

Each USD of equity produced 16 cents of profit this year.

Cash & shareholders
returned in FY2025 · dividends + net buybacks
Free cash flow $M
FY2020 · FCF -86.0
-40M-80M201520172019202120232025

Total assetsUSD 68.9M
EquityUSD 59.0M
CashUSD 40.3M
Current ratio7.59×

Equity funds 86% of total assets.

The 11-year record
11 fiscal years
Every figure from documents filed with the SEC · USD

EPS, diluted, dividend per share and shares outstanding are shown without shading, and a vertical line marks the year the share count changed — the series crosses a large, unexplained change in share count, so the years on either side are not on a comparable scale.

row low → row highnegative
Metric 20252024202320222021202020192018201720162015
Revenue $B0.00.00.00.00.00.00.00.00.00.0·
Operating income $B0.0−0.10.0−0.0−0.1−0.1−0.1−0.0−0.0−0.0−0.0
EBITDA $B0.0−0.10.0−0.0−0.1−0.1−0.1−0.0−0.0−0.0−0.0
Income tax $B0.00.00.00.00.00.00.00.00.00.00.0
Net income $B0.0−0.10.0−0.0−0.1−0.1−0.1−0.0−0.0−0.0−0.0
Free cash flow $B·····−0.1−0.1−0.0−0.0−0.0−0.0
EPS, diluted $0.15−1.270.43−1.23−2.91−3.52−3.35−2.60−17.82−95.87−53.11
Dividend / sh $···········
Payout %···········
ROE %16.3−89.624.9·−81.5−75.8−64.1−41.7−197.9··
Shares out B0.060.050.050.050.030.030.020.020.000.00·

Slide the table for earlier years · "·" marks a figure not available in our data for that year.

Provenance
Company facts, as filed
How we verify · 0 failures in 42 reconciliationsAUDITED

Reconciled in 11 of 19 fiscal years. 34 checks could not be computed.

EPS recomputationBalance-sheet identityGross profitBalance-sheet liquiditymoeda_consistente0 failures
ActivityPharmaceutical Preparations
Listed onNASDAQ
Incorporated inDelaware
Fiscal year endsDecember 31
SEC categorysmaller reporting company
Data on record since2015

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