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MARKETS / NASDAQ / CSTL
NASDAQ · SERVICES-MEDICAL LABORATORIES · MID CAP

Castle Biosciences Inc. CSTL

8 fiscal years on record · USD · FY2025 reported · SEC filings only
$344.2M
▲ 3.7% YoY
$-24.2M
▼ 232.4% YoY
$28.3M
▼ 22.5% YoY
In brief

What this company does

Castle Biosciences offers test solutions to aid clinicians in the diagnosis and treatment of dermatologic cancers, Barrett's esophagus, atopic dermatitis, and uveal melanoma. It operated laboratory facilities in Phoenix, Arizona and Pittsburgh, Pennsylvania in 2025. As of December 31, 2025, it had 883 full-time employees. Revenue from patients covered by Medicare accounted for 44% of its total revenue for the year ended December 31, 2025. Its test portfolio addresses cancers or precancerous diagnoses in the fields of dermatology, gastroenterology and ophthalmology, and, most recently, includes a test to guide systemic treatment decisions in patients with moderate-to-severe atopic dermatitis. Castle Biosciences was incorporated in Delaware in September 2007.

Written from the business description in CASTLE BIOSCIENCES, INC.'s annual report to the U.S. Securities and Exchange Commission, filed 26 February 2026. Every sentence was checked against that document before publication.

Growth
USD 344.2M
Revenue, FY2025 · full 8-year series below
Revenue $M Net income $M
FY2025 · Revenue 344.2 · Net income -24.2
200.0M-25.0M-50.0M20182019202020212022202320242025
Compound annual growth
+35.9%
+40.6%
3 yrs
5 yrs
10 yrs
15 yrs

Revenue compounded at +40.6% a year over five years.

Compound annual rates per period — left blank where that exact year isn't on file, the series crosses a loss, or (per-share rows) a split falls inside the window.

Profitability
−7 cents
lost on every revenue dollar
Operating margin Net margin
FY2025 · Operating -12.4% · Net -7.0%
5%10%-20%-40%20182019202020212022202320242025
ROE
FY2025 · ROE -5.2%
10%20%30%-5%-10%-15%20182019202020212022202320242025

Each USD of equity lost 5 cents this year.

Cash & shareholders
returned in FY2025 · dividends + net buybacks
Free cash flow $M
FY2025 · FCF 28.3
20M-20M-40M20182019202020212022202320242025

Total assetsUSD 578.6M
EquityUSD 470.9M
CashUSD 116.7M
Gross debtUSD 10.1M
Net debtUSD -106.7M
Current ratio5.26×

The company holds more cash than debt.

The 8-year record
8 fiscal years
Every figure from documents filed with the SEC · USD

EPS, diluted, dividend per share and shares outstanding are shown without shading, and a vertical line marks the year the share count changed — the series crosses a large, unexplained change in share count, so the years on either side are not on a comparable scale.

row low → row highnegative
Metric 20252024202320222021202020192018
Revenue $B0.30.30.20.10.10.10.10.0
Operating income $B−0.00.0−0.1−0.1−0.0−0.00.0−0.0
EBITDA $B−0.00.0−0.1−0.1−0.0−0.00.0−0.0
Income tax $B−0.00.00.0−0.0−0.00.00.00.0
Net income $B−0.00.0−0.1−0.1−0.0−0.00.0−0.0
Free cash flow $B0.00.0−0.0−0.0−0.00.00.0−0.0
EPS, diluted $−0.830.62−2.14−2.58−1.24−0.54−0.21−5.33
Dividend / sh $0.000.000.000.000.000.000.000.00
Payout %········
ROE %−5.24.3−14.5−16.6−7.6−4.137.0·
Shares out B0.030.030.030.030.030.020.020.00

Slide the table for earlier years · "·" marks a figure not available in our data for that year.

Provenance
Company facts, as filed
How we verify · 0 failures in 35 reconciliationsAUDITED

Reconciled in 8 of 19 fiscal years. 55 checks could not be computed.

EPS recomputationBalance-sheet identityGross profitBalance-sheet liquiditymoeda_consistente0 failures
ActivityServices-Medical Laboratories
Listed onNASDAQ
Incorporated inDelaware
Fiscal year endsDecember 31
Data on record since2018

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