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MARKETS / NYSE / PLX
NYSE · BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES) · SMALL CAP

Protalix BioTherapeutics, Inc. PLX

17 fiscal years on record · USD · FY2025 reported · SEC filings only
$52.7M
▼ 1.2% YoY
$-6.6M
▼ 325.2% YoY
$-13.6M
▼ 284.4% YoY
In brief

What this company does

We are the first and only company to gain FDA approval of a protein produced through plant cell-based expression in suspension. To date, we have successfully developed two commercial products, both of which are enzyme replacement therapies (ERTs): Elelyso® (taliglucerase alfa) for the treatment of adult patients and children four years of age and older with Gaucher disease and Elfabrio® (pegunigalsidase alfa) for the treatment of adult patients with a confirmed diagnosis of Fabry disease. As of December 31, 2025, we had 226 employees, all of whom are full time employees, and of which 25 have a Ph.D. or an M.D. in their respective scientific fields. We were originally incorporated in the State of Florida in April 1992, and reincorporated in the State of Delaware in March 2016. Protalix Ltd., our wholly-owned subsidiary and sole operating unit, is an Israeli company and was incorporated in Israel in 1993.

Written from the business description in Protalix BioTherapeutics, Inc.'s annual report to the U.S. Securities and Exchange Commission, filed 18 March 2026. Every sentence was checked against that document before publication.

Growth
USD 52.7M
Revenue, FY2025 · full 17-year series below
Revenue $M Net income $M
FY2025 · Revenue 52.7 · Net income -6.6
25.0M50.0M-40.0M-80.0M200920112013201520172019202120232025
Compound annual growth
+3.5%
−3.5%
+28.3%
+14.8%
3 yrs
5 yrs
10 yrs
15 yrs

Revenue compounded at −3.5% a year over five years.

Compound annual rates per period — left blank where that exact year isn't on file, the series crosses a loss, or (per-share rows) a split falls inside the window.

Profitability
−13 cents
lost on every revenue dollar
Operating margin Net margin
FY2025 · Operating -10.4% · Net -12.5%
500%1000%-5000%200920112013201520172019202120232025
ROE
FY2025 · ROE -14.4%
-2000%-4000%-6000%200920112013201520172019202120232025

Each USD of equity lost 14 cents this year.

Cash & shareholders
returned in FY2025 · dividends + net buybacks
Free cash flow $M
FY2025 · FCF -13.6
20M-20M-40M200920112013201520172019202120232025

Total assetsUSD 82.3M
EquityUSD 48.2M
CashUSD 14.7M
Current ratio2.51×

Equity funds 59% of total assets.

The 17-year record
17 fiscal years
Every figure from documents filed with the SEC · USD

EPS, diluted, dividend per share and shares outstanding are shown without shading, and a vertical line marks the year the share count changed — the series crosses a large, unexplained change in share count, so the years on either side are not on a comparable scale.

row low → row highnegative
Metric 20252024202320222021202020192018201720162015201420132012201120102009
Revenue $B0.10.10.10.00.00.10.10.00.00.00.00.00.00.00.00.00.0
Operating income $B−0.00.00.0−0.0−0.00.0−0.0−0.0−0.0−0.0−0.0−0.0−0.0−0.0−0.0−0.0−0.0
EBITDA $B−0.00.00.0−0.0−0.00.0−0.0−0.0−0.0−0.0−0.0−0.0−0.0−0.0···
Income tax $B0.00.00.00.0·············
Net income $B−0.00.00.0−0.0−0.0−0.0−0.0−0.0−0.1−0.00.1−0.0−0.0−0.0−0.0−0.0−0.0
Free cash flow $B−0.00.0−0.0−0.0−0.0−0.0−0.0−0.0−0.0−0.0−0.0−0.0−0.0−0.0−0.0−0.00.0
EPS, diluted $−0.080.040.09−0.31−0.62−0.22−1.23−1.80−6.37−0.290.61−0.32−0.30−0.13−0.43−0.360.41
Dividend / sh $·················
Payout %·················
ROE %−14.47.672.5······−6411.6·····−1271.8−197.9
Shares out B0.080.080.070.050.050.030.010.010.140.120.100.090.090.090.090.08·

Slide the table for earlier years · "·" marks a figure not available in our data for that year.

Provenance
Company facts, as filed
How we verify · 0 failures · 2 divergences in 73 reconciliationsAUDITED

Reconciled in 15 of 19 fiscal years. 2 of those reconciliations are divergences — the figures exist but don't fit the formula this check expects; that isn't the same as an error. 14 checks could not be computed.

EPS recomputationBalance-sheet identityGross profitBalance-sheet liquiditymoeda_consistente0 failures2 divergent
ActivityBiological Products, (No Diagnostic Substances)
Listed onNYSE
Incorporated inDelaware
Fiscal year endsDecember 31
SEC categorysmaller reporting company
Data on record since2009

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